Tramadol hydrochloride tablets are a centrally acting analgesic. The chemical name for tramadol hydrochloride is (±)cis-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride. Its structural formula is: Image from Drug Label Content. Molecular formula: C16H25NO2• HCl Molecular weight: 299.84.
Tramadol hydrochloride tablets may impair mental or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.
In single-dose models of pain following oral surgery, pain relief was demonstrated in some patients at doses of 50 mg and 75 mg.
The base is converted to its hydrochloride and recrystallized from a low molecular weight nitrile such as acetonitrile until a greater than 98% trans/cis ratio A hydrochloride of Tramadol can be synthesized without increasing a ratio of trans:cis by including a step in which HCl is added to Tramadol base in.
The cis form of Tramadol, as that phrase is used herein, includes the S,R and the R,S isomers which are shown by the following two structures:
Of this, 8.6 g was recrystallized from 75 mL of acetonitrile to give 7.44 g, trans/cis ratio of 99.6/0.4. Recrystallization from 90 mL of acetonitrile yielded 8.83 g, which was 96.6/3.4 of trans/cis by HPLC.
For the Examples below, assays were performed to determine the trans/cis ratio of the purified product. Mobile phase B consisted of the phosphate buffer 80%:acetonitrile 20%.
More from. Tramadol Tablets - FDA prescribing information, side effects and uses; http://www.drugs.com/pro/tramadol-tablets.html; The molecular weight of tramadol hydrochloride is 299.8. Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. More from · Side Effects of Ryzolt (Tramadol Hydrochloride.
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The knowledge about the molecular mechanisms, which govern the observed secondary relaxations seems to be the key in predicting the stability of the amorphous form of the examined API. Finally additional dissolving measurements on the amorphous and crystal tramadol hydrochloride were performed.
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2009 Wiley-Liss, Inc. In the case of the hydrochloride tramadol we are able to monitor α-relaxation process despite large contribution of dc conductivity to the loss spectra. Dielectric relaxation measurements as well as differential scanning calorimetry and X-ray diffraction investigations were performed on tramadol monohydrate and its hydrochloride salt.
Tramadol Hydrochloride exporters - UMA Brothers suppliers of Tramadol HCL, Tramadol Hydrochloride exporter, Tramadol Hydrochloride supplier, Tramadol HCl Grade BP/USP/EP; Packing - Offered In Export Worthy Packing Of 25 Kilos Or As Per Our Customer Requirements. Molecular Structure. Molecular Structure.
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