Pharmacist's Letter has a good article, titled "Cross-Reactivity of Sulfonamide Drugs", which provides a good overview of the issue. Here is a pdf of the article from 2005 that I found, which they last updated in 2010. As a brief summary, sulfonamide drugs (defined by the SO2NH2 moiety in their chemical.
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There is also a type 5, or unknow reason for hypersensitivity that involves some unknown stimulation of an immune response (these are generally rashes and discomfort).
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However, there are those that are allergic to more sulfur compounds (sulfate, sulfite) than just the sulfonamide.
There is an association between hypersensitivity after the receipt of sulfonamide antibiotics and a subsequent allergic reaction after the receipt of a sulfonamide nonantibiotic, but this association appears to be due to a predisposition to allergic reactions rather than to cross-reactivity with sulfonamide-based.
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Drug Allergies vs. Pseudoallergies vs. Expected Side Effects. Kaitlyn McDonald, PharmD. Pharmacy Practice Resident. Kootenai Health. March 6, 2016 Pharmacist's Letter 2009. No cross-reactivity between sulfa and any of these agents, but cannot compley rule out the possibility for drugs with a sulfa moiety. Aspirin.
After completing this continuing education article, the pharmacist should be able to:. A true opioid allergy is rare (<1%), however, and is a reaction in which the body's immune system responds in an overstated way (skin rash, facial Cross-reactivity to another analogue class is rare (Table 4).33-37.
Metolazone (Zaroxolyn). None. Cross-sensitivity has not been reported but is a theoretical concern. Rofecoxib (Vioxx). None. Not a sulfonamide; no concerns about use. From Allen J. Which medications to avoid in patients with sulfa allergy. Stockton (CA): Pharmacist's Letter and Prescriber's Letter; 2000. Used with permis.