6.22.2018 | Jose Jacobson

Additional experience reports can be found here:. There are currently no anecdotal reports which describe the effects of this compound within our experience index.

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[5 ] This makes its effects and interactions relatively unpredictable. As a result, high doses or combinations with other psychoactive substances are strongly advised against. Unlike most opioids, tramadol has been established to lower the seizure threshold in humans.

[ citation needed ]. It is often combined with paracetamol as this is known to improve the efficacy of tramadol in relieving pain. Tramadol is marketed as a racemic mixture of both R and S stereoisomers. This is because the two isomers compliment each other's analgesic activity.

[1 ]. Death may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.


WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Tramadol is unique as it is found in a racemate (combination) of its stereoisomers. [8 ]. It is produced as a hydrochloride salt. Tramadol is produced as a racemate of its two isomers because the combination is proven to be more effective. The picture seen above is the R- enantiomer of tramadol, switching the dashed and solid wedges seen on the molecule skeleton results in the S- enantiomer. These are two molecules that share the same chemical structure, but are three-dimensional mirror images of each other.

It is strongly discouraged to combine these substances, particularly in common to heavy doses.

It would take another 20 years for it to be launched in English-speaking countries such as the UK, US and Australia. Tramadol (also known as Ultram, Ralivia or Tramal ) is a synthetic opioid analgesic which is commonly prescribed to treat moderate to severe pain. It was first launched and marketed as Tramal by the German pharmaceutical company Grünenthal GmbH in West Germany. [2 ].

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Instead, tramadol contains two rings that include a cyclohexane ring bonded to a phenyl ring at R 1. Tramadol is loosely analogous to codeine, but is not a morphinan opiate. (+/-)Tramadol, or 2--1-(3-methoxyphenyl)cyclohexanol, is an atypical synthetic opioid. Tramadol features a second substitution on its cyclohexane ring at R 2. At the same location (R 1 ) the cyclohexane ring is bonded to the phenyl ring, an additional hydroxy group is found. This phenyl ring is substituted at R 3 with a methoxy group (CH 3 O-). Here, the ring is bonded to a dimethylamine group connected through a methyl bridge.

It is not a recommendation and should be verified with other sources for accuracy. DISCLAIMER : PW's dosage information is gathered from users and resources for educational purposes only.

As such, it may contain incomplete or wrong information. You can help by expanding it.

Tramadol acts as an opioid receptor agonist, [9 ] [10 ] serotonin releasing agent, [11 ] [12 ] [13 ] [14 ] norepinephrine reuptake inhibitor, [15 ] NMDA receptor antagonist, [16 ] 5-HT2C receptor antagonist, [17 ] (α7)5 nicotinic acetylcholine receptor antagonist, [18 ] TRPV1 receptor agonist, [19 ] and M1 and M3 muscarinic acetylcholine receptor antagonist. [20 ] [21 ]. The R- enantiomer is a selective agonist of the mu receptors and inhibits serotonin reuptake while the S- enantiomer inhibits noradrenaline reuptake. The R- and S- enantiomers of tramadol act on different receptors in a complimentary manner.

It is strongly recommended that one use harm reduction practices when using this drug.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

The euphoric effects of this compound stem from the way in which opioids bind to and activate the μ-opioid receptor. The way in which opioids structurally mimic these natural endorphins results in their euphoria, pain relief and anxiolytic effects. They can be released in response to pain, strenuous exercise, orgasm, or general excitement. This occurs because opioids structurally mimic endogenous endorphins which are naturally found within the body and also work upon the μ-opioid receptor set. This is because endorphins are responsible for reducing pain, causing sleepiness, and feelings of pleasure.

It is also potentially lethal when mixed with depressants like alcohol or benzodiazepines and generally has a wider range of substances which it is dangerous to combine with in comparison to other opioids. Tramadol has a low toxicity relative to dose. It should not be taken during benzodiazepine withdrawals as this can potentially cause seizures. As with all opioids, long-term effects can vary but can include diminished libido, apathy and memory loss.

Tramadol presents cross-tolerance with all other opioids, meaning that after the consumption of tramadol all opioids will have a reduced effect. Tolerance to many of the effects of tramadol develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. The rate at which this occurs develops at different rates for different effects, with tolerance to the constipation-inducing effects developing particularly slowly for instance. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption).

[7 ]. [6 ] These reports later proved to be erroneous; the tramadol had been excreted by cows treated with the drug, resulting in the tramadol having seeped into the roots through their urine. For a period of time it was believed tramadol was not a purely synthetic drug after its apparent discovery in the roots of the pin cushion tree.

The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances.

Combinations in the list below may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels.

[3 ] [4 ] Tramadol is metabolised to O-Desmethyltramadol ( O-DSMT ), a significantly more potent opioid. Tramadol is a reuptake inhibitor of norepinephrine and serotonin and a weak μ-opioid receptor agonist.

As such, it may contain incomplete or wrong information. You can help by expanding it.

When addiction has developed, cravings and withdrawal symptoms may occur if a person suddenly stops their usage. As with other opioids, the chronic use of tramadol can be considered moderay addictive with a high potential for abuse and is capable of causing psychological dependence among certain users.